The 31-year-old rejoined Spurs on a season-long loan from Real Madrid last month.
And this is the first time he has made a Tottenham matchday squad in his second spell after recovering from a knee injury.
Bale left Spurs to join Real Madrid in a then world record £85million deal in 2013.
With Harry Kane and Heung-min Son in fine goalscoring form, the Wales star will be itching to link up with them on the pitch.
Elsewhere, Dele Alli, who was heavily linked with a summer move to Paris Saint-Germain, has been dropped from the squad.
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Meanwhile, West Ham are unchanged from their impressive 3-0 win over Leicester before the international.
Hammers boss David Moyes returns to the dugout after missing the last four matches due to a positive coronavirus test.
Tottenham XI: Lloris, Aurier, Alderweireld, Sanchez, Reguilon, Hojbjerg, Sissoko, Ndombele, Bergwijn, Kane, Son.
Substitutes: Hart, Doherty, Davies, Winks, Lucas, Bale, Vinicius.
West Ham XI: Fabianski, Balbuena, Ogbonna, Cresswell, Coufal, Rice, Soucek, Fornals, Masuaku, Bowen, Antonio.
Substitutes: Randolph, Fredericks, Diop, Noble, Snodgrass, Lanzini, Yarmolenko.
Gareth Bale has been named on the bench for Tottenham's Premier League clash with West Ham.