Pickford avoided a red card for his early clash with Liverpool defender Van Dijk, with refereeing board PGMOL later explaining it was subjectively decided the Everton goalkeeper had tried to play the ball.
But he flew in high and scissored his legs across Van Dijk, who crumpled to the ground and may now miss up to EIGHT months with an ACL injury.
This would mean Van Dijk misses the entire remainder of the 2020/21 season, and while Liverpool have not confirmed the extent of the injury manager Jurgen Klopp admitted his fears after the match.
"Virgil played I don't know how many games in a row, he plays with pain, but he couldn't play on," said Klopp. "That's not good."
Pickford has been widely criticised since the match, while many pundits believe it was the incorrect decision to let him stay on the pitch after putting in such a poor challenge.
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And talkSPORT's very own Cascarino - the former Chelsea and Republic of Ireland forward - believes Pickford's tackle was as bad as Keane's on Haaland in 2001.
That Manchester derby challenge is widely considered to be the worst tackle EVER seen in the Premier League, with Keane later admitting it was an act of vengeance against Haaland for an incident between the pair a few years earlier.
But this tackle now joins Keane on Haaland as one of English football's most horrific, Casc claims.
Speaking on Sunday's Weekend Sports Breakfast, Casc said: "The challenge… just, wow! We give yellow cards so readily and so quickly for minor incidents, and then you see a tackle that is as bad as the one Roy Keane did on Alf-Inge Haaland.
"It was just horrendous!
"We talk about dangerous tackles and two-footing and lunging in and being reckless - Jordan Pickford was everything as bad as it could be.
"I don't think you can ever say it's intentional - only the player can answer that - but if you are going to throw yourself, launch yourself, at somebody out of control…
"When I saw it I thought, 'wow!'
Tony Cascarino believes Jordan Pickford's tackle on Virgil van Dijk during Saturday's Merseyside derby was as bad as the challenge Roy Keane famously put in on Alf-Inge Haaland.